Science of Longevity
Unlock the secrets of time
Dive into the Science of Longevity! Explore the inner workings of cellular stability and renewal mechanisms, unravelling the keys to extended healthspan and initiating your healing factors. We specialize in exploring the intricate pathways of aging, offering insights that pave the way for transformative breakthroughs. Join us in the quest to have a more vital and vibrant future!
Science of longevity
Get your lifestyle in line with the science of longevity.
Maintenance of the circadian system
Combined cardiovascular & resistance exercise
Enhancement of autophagy
Elimination of senescent cells
Stimulation of adult neurogenesis
Nutrition of essential nutrients and minerals
Biotechnology and medical drugs
Emotional & mental stability
Thermotherapy
Whether it is having more years of life or more life in the years you have, Timeline Sciences is here to help.
Safeguarding genomic integrity ranks highest in priority for longevity. Stability of proteomic function ensures quality of life well into the years. Metabolites carry signals and the earliest warnings of possible damage.
Science of longevity
The science of longevity centres around the integrity of the cell.
Current research supports two main paradigms of aging
Genetic | Programmed based aging
Lifespan | Acquired damage-based aging
The cellular component of longevity supports the functional capacity of the overlaying physiology.
Frequently Asked Questions
Genetics may lower or raise the bar for longevity, however, it is the actions that become habits, the lifestyle that ultimately determines whether we fall short or exceed genetic predictions. The genome itself must be protected, as the genome is the source of information for the continual renewal of proteins necessary to carry out functions for the cell.
Your grandparents’ age is a better predictor of longevity than any genetic loci to date. Some loci of the genome have been identified to confer an impact on aging like ApoA1. Knowing those genes gives you information on the biological pathway, aiding your actions to adjust the bar genetics has set, knowing where to tread carefully and more comfortably.
Epigenetics plays a crucial role in allowing cells to respond and adapt to their environment through changes in gene expression. Epigenetic clocks based on DNA methylation patterns are better predictors of mortality risk than chronological age. Exercise is one modality that alters DNA methylation and reverses these epigenetic clocks.
Definitely. Metabolites are small molecules such as lipids, amino acids, short peptides, vitamins, sugars, or alcohols and over a million are estimated within humans. Metabolites are the downstream products of genes and proteins and can differ from cell and tissue types. Metabolites are very sensitive to internal and external signals and can fluctuate in concentration throughout the day making them quite a bit harder to interpret in biological age calculations.
Whereas the genome (genotype) is a set of information holding the potential of what might happen, the metabolome (metabotype) indicates what is happening. The metabolome is the chemical readout. Genetic factors significantly influence the metabolome, affecting metabolite levels and metabolic pathways. Knowing more about your lineage aids in proper comparisons.
Yes. Antioxidants like glutathione, metabolites involved in anti-inflammatory pathways (e.g., certain polyphenols), and metabolites supporting mitochondrial function (e.g., coenzyme Q10) are linked to reducing the risk of age-related diseases, including neurodegenerative disorders, cardiovascular diseases, and metabolic disorders.
Definitely. Proteins are the workhorses upholding cellular functions, enabling biochemical reactions, regulating gene expression, and serving as signalling molecules. Their concentration is often telling of the strength or frailty of their supporting physiological function. Changes in protein function with age impact cellular homeostasis and contribute to age-related decline.
No single protein can capitulate the complexity of aging and can be subject to context for interpretation. Biotechnology has improved the quantity of proteins that can simultaneously be measured, which increases confidence in predicted trends. A panel of 50-100 proteins is attainable today by various vendors, and consistency is king. Having the same panel over several years is far more useful than different panels.
Though panels of blood biomarkers provide insights into specific biological pathways to address, the overall best measurements are associated with cardio-respiratory fitness. Maximal oxygen capacity and forced expiratory volume stand currently as the best predictors of healthspan. However, these measures lack the sensitivity that the blood-based biomarkers can fulfill. A combination of blood biomarkers and functional testing are best practice.
We provide curated information and current research findings. We work with your ambition and ability to incorporate lifestyle interventions that would benefit you. We do not provide medical advice or act as a substitute for your healthcare provider.
No. You will be asked about goals and aspirations as a minimum to get started. We can help recommend and connect you to the various testing currently available on the market.
Yes. Take a look at our Comprehensive Timeline service or scientific consulting service for any data analysis needs.